What oral ulcers indicate pemphigus vulgaris

is an autoimmune disease of the mucous membranes and skin. This process is based on a violation of adhesion between the epidermal cells of the skin, called acantholysis. It is acantholysis that promotes the binding of autoantibodies to keratinocytes. Evidence of the autoimmune nature of pemphigus is obtained

in the blood serum of patients using direct and indirect fluorescence methods. Clinically, pemphigus is divided into two types - pemphigus vulgaris and pemphigus foliaceus.

Read more about pemphigus vulgaris at

, because in dermatological practice this form of pemphigus is the most common.

• Causes and mechanism of development of pemphigus vulgaris
• Characterization of pemphigus vulgaris antigens
• What is the clinical picture of pemphigus vulgaris
• Methods for the specific diagnosis and treatment of pemphigus vulgarisand
Causes and mechanism of development of pemphigus vulgaris

Many autoimmune processes are caused by

. This means that in the process of the formation of the immune system, defective selection of T cells in the thymus occurs. Thus,

which can recognize the autoantigen complex - a molecule of the 2nd class of the major histocompatibility complex, get to the periphery. Selection is based on the recognition of such a complex by

in the thymus and the excretion of recognizing T-cells within the thymus. This process is disrupted in the presence of features of the class 2 MHC molecule, which is polymorphic in people with different genotypes. That is, it is the

of a person's predisposition to pemphigus vulgaris.

Facebook ! Characterization of pemphigus vulgaris antigens

Studies have shown that pemphigus vulgaris produces

. After autoantibodies bind to keratinocyte membranes, acantholysis begins, which is accompanied by

. It has been proven that inflammatory cells and the complement system are not involved in the above process, however, the presence of the latter can increase the

. When an infection enters the skin lesions, a

develops, which significantly worsenst the clinical picture and the patient's condition.

What is evidenced by the onset and progression of pyoderma in adults What is the clinical picture of pemphigus vulgaris

As a rule, the first symptom of pemphigus vulgaris is

In the process of eating, these bubbles are damaged, and in their place rather painful bright red erosions appear. The top film of the burst bubble covers the erosion, giving the impression of a white coating on the erosion. At this stage, a patient with pemphigus vulgaris rarely sees a doctor.

Over time, erosions grow and unite, which is accompanied by increased pain in the oral cavity. With such a picture, a person

bad breath appears, it is difficult for the patient to speak. After a few months, bubbles appear on the body. Variants of the course of pemphigus vulgaris are known, when the vesicles appeared both on the skin and on the mucous membranes at the same time.

Blisters on the body are filled with a clear liquid and are not accompanied by any    sensations.

The bubbles on the skin also increase in size, unite with each other, burst, leaving red erosions behind. At this stage, the patient develops subfebrile temperature and malaise.

When an infectious process is attached,

pyoderma develops. If you do not seek qualified help at this stage, sepsis and death may develop a.

All the dermatologist needs to know about topical glucocorticoids Methods of specific diagnosis and treatment of pemphigus vulgaris

The main symptom of pemphigus vulgaris is pathological

of the epidermis. If the patient has specific complaints, the doctor checks

. To do this, he pulls back the wall of the burst bubble and, if the skin exfoliates at some distance from the focus, then the symptom is positive. Also, to diagnose pemphigus vulgaris, you can press your finger on the bladder, then the skin will peel off at the edges, increasing the area of ​​\u200b\u200bthe lesion.

biopsy
• fresh bladder;
cytological examination;
microscopy of a smear
• - an imprint from the bottom of the bubble.

Treatment of pemphigus vulgaris consists of taking high doses of corticosteroid drugs with gradual dose reduction. It is also advisable to prescribe

to accelerate remission. Later,

is performed to clear the blood of antibodies.

do not exist for pemphigus vulgaris. Patients suffering from this disease need to take maintenance doses of corticosteroid drugs for the rest of their lives.

Peculiarities of Skin Biopsy: A Practical Guide for Physicians

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