Anogenital warts are benign skin lesions caused by the human papillomavirus and located on the genitals and in the perianal region. At the moment, among the modern means of treating anogenital warts, drugs with a local immunomodulatory effect are in the first place in terms of effectiveness.
Anogenital warts (Condylomata acuminata) are benign skin lesions caused by the human papillomavirus and located on the genitals and in the perianal region. They are small, often multiple formations in the form of finger-like outgrowths, papules or spots. They are painless, but tend to break and bleed, increasing the risk of infection. In women, they are located on the labia minora and labia majora, clitoris, vaginal walls, cervix, and in the perianal region.
Methods of treatment of anogenital warts
Most of the treatments used use various methods of surgical or pharmaceutical removal of warts. Surgical methods include laser, radio and electrocoagulation, cryodestruction, resection. To pharmaceuticals - cauterization with trichloroacetic acid and complex acid preparations, for example, Solcoderm.
The disadvantages of these methods include:
- The need for the procedure in the clinic.
- Painfulness of the procedure, often there is a need for local anesthesia.
- Violation of the skin, the appearance of open wounds, which, due to the localization of AHC, creates significant discomfort for the patient.
- Due to the invasiveness and traumatic nature of the treatment, there is a risk of scars, scars, skin pigmentation disorders.
Destructive treatments are quite effective, but after them, 30-70% of patients experience warts recurrence within 6 months. The reason for this is the impossibility of removing all cells affected by the virus, because. the doctor removes only visually altered areas of the skin, while other areas of the skin may be infected with a virus, but are not externally changed. It is these masked areas that become foci of relapses in the future.
Among modern remedies for the treatment of anogenital warts, drugs with a local immunomodulatory effect take the first place in terms of effectiveness.
Immunomodulators act on TLR7 receptors located on the surface of dendritic cells, monocytes and macrophages, which causes a local immune-inflammatory reaction. As a result, HPV-infected cells are damaged and become available to other elements of the immune system. In the future, the immune system itself most accurately determines the affected cells and eliminates the infected areas. It is due to this accuracy that a low percentage of relapses (9-14%) is ensured.
In 1998, immunomodulators were approved in Europe and the United States for the treatment of vulvar and/or perianal warts and are now the accepted treatment for this group of diseases.
According to the site kondiloma.info
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