Lift up ревитализация – современная методика интенсивной терапии соединительной ткани

Connective tissue creates the frame of all organs and tissues, forms the basis of the dermis, and also forms septa, ligaments and fascia, which hold the soft tissues of the face.

Changes in the elastic properties of these structures form folds and wrinkles and lead to changes in facial contours in the form of gravitational ptosis and skin laxity. Therefore, the processes of connective tissue involution are the main point of influence for modern revitalizing therapy.

In this article estet-portal.com Petrovich Andrey Viktorovich – dermatologist-cosmetologist of the Aesthetic Consilium Clinic, scientific director of TOTIS, scientific director of the APIC Congress (Ukraine) talks about the new method of Lift up revitalization. 

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Petrovich Andrey Viktorovich – dermatologist-cosmetologist of the Aesthetic Consilium Clinic, scientific director of the TOTIS company, scientific director of the APIC Congress (Ukraine).  Broad-spectrum revitalization for positive stimulation of connective tissue

The main

pathogenetic mechanisms

of the development of involutional changes are a decrease in the activity and number of cells (fibroblasts and MSCs), as well as a decrease in the synthesis of collagen and hyaluronic acid. Therefore, complex therapy should be aimed at activating cells, restoring their number, creating the necessary microenvironment, and stimulating the synthesis of collagen and hyaluronic acid.

To do this, we have proposed a

complex procedure

that combines positive and negative stimulation. For positive stimulation, we chose a broad-spectrum revitalizing drug Plinest with a concentration of polynucleotides of 2% (20 mg/ml). 

Plinest

– a broad-spectrum revitalizer to stimulate the activity of the cellular link (keratinocytes, fibroblasts, chondrocytes, osteocytes), creating favorable conditions for the work of cells – neoangiogenesis, and activation of the processes of regeneration and restructuring of the connective tissue. 

Plinest

(from company TOTIS) has been well studied in both experimental and clinical scientific studies, which are published in PubMed.  Revitalization with polynucleotides: mechanism of action and effects

There are two proven

mechanisms of

polynucleotides (for polynucleotides from Mastelli):

connection with the A2a receptor, which triggers revitalization, restructuring, anti-ischemic action, neoangiogenesis, anti-inflammatory action, etc.;
  • pathway of reutilization of drug nucleotides.
    • The nucleic acids of the drug are used by the cell to
build its own polynucleotides

– DNA and RNA, which are then used for a long time for the active work of the cell. 

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Plinest are effective in the following areas: 

1. Revitalization

: scientific studies have shown stimulation of fibroblast proliferation, accelerated re-epithelialization of the epidermis, restoration of cartilage and bone tissue.

2. Connective tissue restructuring

: histological sections show that skin damage (incision) is repaired quickly and maintaining the correct structure of the fibrous framework of the dermis. I.e. Plinest provides the conditions for the formation of the correct collagen network in the connective tissue, which makes

Plinest

therapy necessary before using collagen-stimulating drugs, such as calcium hydroxyapatite.

3. Neoangiogenesis

– Plinest stimulates the growth of the microvasculature by stimulating the synthesis of VEGF (endothelial growth factor). Growth of the vessels of the microcirculatory network allows you to restore the nutrition of the soft tissues of the face and ensure the active work of fibroblasts in the synthesis of hyaluronic acid and collagen, and provide them with the necessary nutrients. Create a microenvironment for fibroblasts.

The use of PDRN preparations is mandatory

in the treatment of hair loss

as basic therapy.

4. Anti-ischemic action

– Plinest ensures the active and efficient work of fibroblasts (chondrocytes, osteoblasts) in conditions of insufficient blood circulation. The anti-ischemic effect is mediated through the mobilization of collateral blood flow and a decrease in tissue energy consumption for nucleotide synthesis.

This property is especially important when combined with intensive damaging procedures (laser resurfacing), after plastic surgery, or in case of acute ischemia after the introduction of fillers for accelerated skin recovery.

5. Anti-inflammatory action

– in studies, Plinest showed anti-inflammatory activity comparable in strength to hormonal corticosteroid preparations. This helps to reduce the soft tissue reaction after injection, soreness and redness. This property is especially important when combined with damaging procedures (laser, intensive peeling, microneedling) or after operations.

6. Depigmenting action

– Plinest inhibits the action of tyrosinase, which reduces the production of melanin, and also reduces the accumulation of melanin in keratinocytes and melanophages. Therefore, it is necessary to use it in complex programs of depigmenting therapy.

7. Protection against ionizing radiation

. The drug Plinest in studies has shown a protective effect for tissues from UV and ionizing radiation. Its use for the prevention of photodamage to the skin before hyperinsolation has been justified.

8. Long lasting result

– provided by recycling of nucleotides. Any process in a cell begins with the activation of the corresponding gene, and then the creation of RNA occurs, and only then information is read from the RNA and the necessary process starts. The amount of RNA in an inactive cell is small, therefore, when the cell is activated, the energy-consuming process of synthesis of nucleotides begins first, which will be used to build RNA.

In tissues subject to the aging process, there is a

lack of energy and building materials

for the synthesis of their own nucleotides, so we see that the stimulus is not always realized as a result. Plinest stimulates revitalizing processes through the A2a receptor and simultaneously supplies the necessary amount of nucleotides for the synthesis of its own DNA and RNA molecules.

The duration of stimulation of the A2a receptor is short, but the work of reutilized nucleotides is very long. Therefore,

stimulation started through the A2a receptor

will be implemented for a long time through the mechanism of nucleotide reutilization.  Results of different orientations allow you to get a synergy effect on the final result of revitalization. 

Company

Mastelli (official representative of – TOTISPHARMA GROUP LTD. ) has a unique technology for the purification and fractionation of polynucleotides, which results in a product with a certain distribution of molecular weights of polynucleotides and with preserved biological activity. A different production technology leads to the creation of a different product, for which it is necessary to demonstrate its mechanism of action and biological effectss.  Lift up therapy technology: synergy effect on the end result of revitalization

Results of different orientations allow you to get a synergy effect on the final result of revitalization. 

Modern trends anti-age medicine – polynucleotides for skin rejuvenation  That's why we created

Lift up therapy

technology, which allows you to get instant revitalizing lifting and is based on an innovative author's technique (PDRN injections + MCA biorevitalizing peeling), which leads to intensive restructuring of the connective tissue, reveals the regenerative potential of cells . To do this, we use in one procedure positive stimulation of facial soft tissues using various microinjection techniques with Plinest (2% PDRN) and negative stimulation due to biorevitalizing peeling MCA 35 (35% monochloroacetic acid + 7% salicylic acid + 10% Arbutin ). 

Revitalization protocol

Lift

up revitalization Plinest + MCA 35: 

Make-up remover, gentle skin cleansing with
    Soft Cleanser
  1. (Innoaesthetics). Antiseptic skin treatment.
  2. Topical anesthesia.
  3. Antiseptic skin treatment.
  4. Plinest
  5. : ligament injections (ORL, zygomatico-malar, nasolabial) with a 32G 12mm needle in tunnel technique + microinjections into the deep dermis with a 32G 4mm needle, angle of inclination 30-40 degrees ; for the whole needle micro-injection + reinforcement with a 32G 12mm needle of the mandibular line and lateral parts of the face in a linear – retrograde technique. Antiseptic skin treatment.
  6. Degreasing
    7. Degreasing
  7. Solution (Innoaesthetics). Application in one layer of
    8. peeling MCA 35
  8. (consumption per procedure 1–1.5 ml). Skin reaction control. If there is no frost and redness, then cover with
    9. Skin Repair Innoaesthetics
  9. cream after 15 minutes without rinsing. If there is frost or severe redness, rinse with cold water. Then close with cream
    10. Skin Repair Innoaesthetics
  10. . 
    11. Only patients who have normal, combination or oily skin, and also have sufficient regeneration potential and do not have increased skin sensitivity are suitable for this procedure. 

The combination of positive and negative stimulation in one procedure allows you to get a synergy of effects and an instant result, which manifests itself in lifting the skin and soft tissues of the face, brightening the skin color and leveling its surface. 

The procedure is tolerated by patients comfortably.
The use of fine needles

avoids visible marks on the skin.

Microdoses of

injected into the correct layer do not form a visible papule. Maximum –  an uneven skin texture (with thin skin) may be visible during the day. 

A unique biorevitalization procedure with polynucleotides for rejuvenation of the neck and décolleté area  Injections into the ligaments give a moderate lifting of soft tissues in the middle third of the face, immediately visible after the procedure.

 

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Photos before and after the procedure

 

MCA Peeling

allows you to tone and tighten the skin. Its surface becomes smooth, brightened and acquires a healthy light pink hue. In the rehabilitation period (with the right choice of the patient), there is a moderate, imperceptible to others, small-lamellar peeling, or there is no peeling at all. 

The combination of positive and negative stimulation

in one procedure allows you to get a synergy of effects and instant results, which manifests itself in: 

lifting of the skin and soft tissues of the face;
  • skin lightening;
  • leveling its surface. 
    • The effectiveness of such a procedure depends on the correct selection of patients, drugs and methods of the procedure.