Contouring with the use of various injectable preparations is gaining high popularity today, since the substances that make up corrective fillers have an excellent stable effect, and the result is often quite comparable with plastic surgery.
Not so long ago, readers of estet-portal.com learned about the features of collagen stimulation using Delice Hydroxy fillers, which were described by Andrey Danilyuk, an aesthetic surgeon, a specialist in regenerative medicine, a certified trainer of the company OnCosmetics for invasive techniques in aesthetic medicine. Today we offer a new doctor's material dedicated to hyaluronic acid fillers.
The role of mannitol in hyaluronic acid stabilization
The use of fillers based on hyaluronic acid for Injection contouring and volumetric modeling has become one of the most popular and sought-after techniques among patients today. "Hyaluronka", as cosmetologists call it, meets almost all the requirements that specialists could make for an "ideal" skin. material for injectable plasty: it has a high safety profile, is non-toxic, does not cause allergic reactions, and is biocompatible with the skin and subcutaneous tissue.
Preparations based on hyaluronic acid allow to achieve a corrective effect immediately after the procedure (and even during it), and over time, it undergoes complete biodegradation.
In addition, in case of complications or if the results of the plastic surgery do not satisfy the doctor or patient, you can “roll back” thanks to the methods of rapid forced resorption of the implanted material.
However, as is often the case, there can be a fair amount of fly in the ointment in a barrel of honey. In the case of hyaluronic acid, this fly in the ointment is not as high as we would like, the duration of the action of drugs based on it: the corrective effect usually lasts no more than 1 year, so after 6-7 months it is necessary to carry out repeated procedures. This is due to the partial degradation of hyaluronic acid under the action of hyaluronidase enzymes, but reactive oxygen species (free radicals) have a particularly strong destructive effect on it.
Free hydroxyl radicals accumulate at the injection site and trigger a cascade of oxidative reactions that are chain-like, i.e. having arisen, they are already developing incrementally.
It would be logical to assume that it would be possible to slow down the degradation of hyaluronic acid, which is part of the filler, thanks to some substances that prevent the damaging effect of free radicals and enzymes on it. This is exactly what the specialists of the French cosmetics company did when they created the Philosophy Soliderm line of preparations based on stabilized hyaluronic acid, which include mannitol as an antioxidant.
What are the features of mannitol, which is part of the fillers?
Mannitol, which has a pronounced antioxidant activity (the ability to bind free radicals), has been used in clinical practice for quite a long time. It is used as an osmotic diuretic and decongestant, in particular in cardiology, vascular and cardiac surgery. Now mannitol has found application in cosmetology. The introduction of mannitol into the composition of Soliderm preparations makes it possible to prevent the oxidative degradation of hyaluronic acid by free radicals, as well as its enzymatic degradation by hyaluronidases (by preventing the development of acidosis in post-traumatic inflammation).
Due to the use of mannitol, Soliderm fillers last much longer than conventional hyaluronic acid-based fillers, and the effect of injection plastics with their use lasts up to 2 years.
It should be noted that mannitol in the composition of Soliderm preparations begins to work, as they say, "at the tip of the needle"; – it significantly reduces the likelihood of developing an inflammatory reaction at the injection site and prevents oxidative degradation of hyaluronic acid immediately after its injection under conditions of tissue injury with a needle. In addition, mannitol – a hydrophilic substance, it binds water more stably than hyaluronic acid, therefore it prevents such a common complication as transient edema.
Another important advantage of mannitol – a change in the optical density of the drug, which prevents the occurrence of the Tyndall effect (scattering of light when passing through an inhomogeneous medium), which manifests itself in the form of a bluish glow through the skin when the drug is superficially injected, especially in the area of \u200b\u200bthin skin.
Help. "Mannitol is a diuretic moisture-removing agent, it is used in cosmetics to a limited extent, it can remove excess moisture from the body. Mannitol is an inhibitor of the breakdown of hyaluronic acid, increasing the period of its active action on the skin"
Features of the use of fillers containing mannitol
Soliderm 2 (stabilized hyaluronic acid 20 mg/ml, mannitol) is used to correct superficial and fine wrinkles, crow's feet around the eyes, wrinkles of the forehead and between the eyebrows, oral wrinkles, as well as reinforcement of the décolleté.
The use of Soliderm preparations for injectable plasty not only allows increasing the internal volume of tissues, but also stimulates neocollagenesis, expression of connective tissue growth factor, as well as consistent skin restructuring. The use of mannitol in the composition of Soliderm fillers makes it possible to slow down the process of biodegradation of hyaluronic acid, promotes a more intense and prolonged process of collagen synthesis, restores water balance and skin elasticity, i.e. her natural rejuvenation and slowing down her aging processes.
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