According to recent studies, the use of macrolides (excluding erythromycin), quinolones, tetracyclines, sulfonamides and metronidazole during early pregnancy was associated with an increased risk of spontaneous abortion.
Although antibiotics are widely used during pregnancy, evidence of their safety in the fetus remains limited.
Are there any associations between exposure to antibiotics during pregnancy and the chance of spontaneous abortion, find out at estet-portal. com in this article.
- Risk factors for spontaneous abortion
- Why antibiotics can be dangerous for the embryo
- Which antibiotics increase the risk of spontaneous abortiona
Risk factors for spontaneous abortion
Spontaneous abortions may result from infection with certain viruses, in particular:
- cytomegalovirus;
- herpesvirus;
- parvovirus;
- rubella virus.
Other causes of spontaneous abortion include immunological disorders, severe uterine changes (eg, fibroids, adhesions, and trauma).
for spontaneous abortion include:
Age > 35;- history of spontaneous abortion;
- smoking;
- use of certain medications (including antibiotics);
- poorly controlled chronic illness in mother
- In the early stages of pregnancy,
are a particular risk, since in modern realities they are very often taken uncontrolledo.
Progesterone during pregnancy: the pros and cons of increased hormone secretion Why antibiotics can be dangerous for the embryo
Many classes of antibiotics are associated with an increased risk of spontaneous abortion.
1.A possible mechanism explaining this effect for clarithromycin involves its proarrhythmic properties (via potassium channel inhibition) that play a role in heart rate regulation in early embryonic development.
2. The quinolonecan act as a DNA gyrase inhibitor as well as a mitosis inhibitor.
3. Tetracyclineinhibits the production of pro-inflammatory cytokines as well as matrix metalloproteinases, which are known to play a role in tissue remodeling, trophoblast invasion, and endometrial decidialization.
Read the most interesting articles inTelegram! Which antibiotics increase the risk of spontaneous abortion
After adjusting for potential risk factors
, increased risk of miscarriagein early pregnancy has been associated use:
macrolides (excluding erythromycin);- quinolones;
- tetracyclines;
- sulfonamides;
- metronidazole.
has not been associated with an increased risk of spontaneous abortion. This finding supports its use as an
alternative to trimethoprim-sulfamethoxazolefor the treatment of urinary tract infections during pregnancy. Exposure to metronidazole has been associated with a 70% increased risk of spontaneous abortion.
Thus, antibiotics should be given very carefully in early pregnancy so as not to provokespontaneous abortion
. The most safe are
penicillin antibiotics, but they can also adversely affect the fetus. Read also:
Fluconazole during pregnancy: a hidden danger
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