Новый биоклей сможет остановить кровотечение из крупных сосудов

Serious injuries and major surgeries are rarely the cause of a patient's death, but blood loss can lead to lethal outcome.

In case of heavy bleeding, it is very important to provide first aid in a timely manner.

In this regard, specialists are constantly looking for ways to quickly and effectively stop bleeding.

Chinese scientists have developed a unique bio-adhesive that they hope will one day be able to prevent uncontrolled bleeding from large vessels.

More about the invention on estet-portal.com in this article.

Bioglue will help stop bleeding

Chinese researchers have developed what they call "biological glue".

According to the authors, all modern models of bleeding prevention, known in medicine as hemostatic agents, suffer from the same problem – they do not control bleeding well due to their poor adhesion to wet and mobile tissues.

A team of scientists decided to imitate the extracellular matrix, which acts as a cell binding agent.

The most abundant protein in the human body, collagen, is located in the extracellular matrix and is the building material for the connective tissues of the bodyzma.

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Study of adhesion and mechanical strength of bioadhesive

The adhesive strength of a hydrogel

is one of the most important factors for cardiac and arterial hemostasis, as the hydrogel must attach quickly to stop bleeding when arterial blood vessels are damaged.

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Injection of hydrogel into the area of ​​the incision on the pig's heart stops bleeding

The hemostatic performance is mainly dependent on the weakest properties of the materials used, and if the adhesion force is higher than the mechanical strength of the gel, the hydrogel may rupture under the pressure of pulsating blood vessels.

Material strength tests showed that the adhesive biological hydrogel had
sufficient internal strength

and the ability to form strong bonds with the tissue substratumvolume.

Invisible threads: a refined cosmetic suture technique Biocompatibility and biodegradation of matrix gel

Good biocompatibility

is an essential property of hemostatic adhesives. The cellular cytotoxicity of these hydrogels was initially assessed by co-incubation with fibroblast cells.

Hydrogel-exposed cells and untreated control cell cultures proliferate similarly, and moreover, treated cells migrate into the hydrogel as the culture develops.

Finally, this hydrogel was implanted subcutaneously in rats to assess
in vivo biodegradation

and local interaction of the implant with animal tissues, as well as host cellular immune response. The results of the study showed that

the hydrogel is gradually degraded

.

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The hemostatic agent
must not interfere with wound healing

, be toxic, or cause severe inflammation. Hematoxylin and eosin staining showed that several inflammatory cells appeared near the hydrogel-tissue interface, indicating that, as expected, there was a

postoperative inflammatory response

. However, this inflammatory response

gradually disappeared

and progressive growth and migration of non-inflammatory dividing cells occurred within 2 weeks. These results indicate

good biocompatibility

and reduced cytotoxicity of hydrogenel.

Suture material: which sutures should the surgeon prefer While bioglue is being tested

Although BioGlue has not yet been tested on humans

, it has shown phenomenal success when tested on

pig hearts, which have a lot in common with human hearts. This is the first time that high pressure bleeding

from a beating heart with a diameter of 6mm has been quickly stopped and the wounds have been stably closed.

Scientists used only matrix gel for 20 seconds without suturing

.

Hongwei Ouyang

, co-author of the study, reports that this biological gel is expected to be available for general use within

3-5 years.

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