Psoriasis is one of the prevailing inflammatory dermatoses and is observed in 2-3% of the population, which is more than 125 million patients worldwide. There are many drugs that alleviate the condition of the patient however, a complete cure does not occur. A similar clinical picture occurs in the case of autoimmune diseases. What other diseases can psoriasis signal and what is the relationship between them? Read more about the association of psoriasis with autoimmune diseases at ester-portal.com.
- Peculiarities of psoriasis as a systemic disease
- Results of examinations of patients with psoriasis
- Conclusion
Peculiarities of psoriasis as a systemic disease
Psoriasis is a chronic non-infectious disease that mainly affects the skin, the elements of the lesion are the so-called papules, which merge and form plaques on the skin. The etiology has not been fully studied, but scientists suggest 2 main components in the development of this dermatosis, such as :
- genetic predisposition
- autoimmune reaction of the body
Indeed, the data confirm the special role of the immune system in the pathogenesis of psoriasis, namely the T-cell component. Modern medicine is increasingly saying that psoriasis is a T-cell disorder that involves multiple interactions of sensitive gene loci and various factors environment.
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All of the above facts suggest that the incidence of autoimmune disease among patients with psoriasis should be much higher than in the general population.
Chromosome 16 is involved in conferring susceptibility to psoriasis, Crohn's disease, and ulcerative colitis, and chromosome 4 links psoriatic arthritis and possibly psoriasis to a variety of autoimmune diseases, including type 1 diabetes, celiac disease, and Graves' disease (diffuse goiter).
Information about the involvement of the genetic apparatus in the development of these diseases confirms the
Information needed for the study included demographics and inpatient and outpatient visits. In the context of the relationship between psoriasis and autoimmune diseases, the following diagnoses were of interest:
Crohn's disease,
- ulcerative colitis,
- type 1 diabetes,
- Alopecia areata,
- hemolytic anemia,
- systemic lupus erythematosus,
- Graves' disease,
- Hashimoto's disease,
- Sjögren's syndrome,
- immune thrombocytopenia,
- rheumatoid arthritis.
A retrospective study analyzed 25 341 people diagnosed with psoriasis, half of whom were men. All patients with psoriasis showed a higher ratio in the presence of all listed autoimmune diseases.
The most notable associations were with rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, systemic sclerosis, celiac disease, giant cell arteritis, and hemolytic anemia.
Statistics show that women are more likely to suffer from autoimmune diseases than men, while blacks and Mediterraneans, on the contrary, have fewer cases of autoimmune diseases.Read also:
Modern methods of treating psoriasis As previously mentioned, the most common autoimmune disease in patients with psoriasis is rheumatoid arthritis, but it is likely that the diagnosis may be confused with psoriatic arthritis. However, this problem does not arise often, as rheumatologists clearly rely on classification criteria. Rheumatoid arthritis includes joint involvement, serological parameters such as positive rheumatoid factor, C-reactive protein, and duration of arthritis.
- typical psoriatic nail dystrophy;
- negative rheumatoid factor test by any method, current dactylitis or history of dactylitis recorded by a rheumatologist;
- X-ray evidence of juxta-articular new bone formation that appears as ill-defined ossification near the joint margins (but excluding osteophyte formation) on plain radiographs of the hand or foot.
Peculiarities of the clinical picture and treatment of nail psoriasis Psoriatic arthritis occurs in 7%-26% of cases in patients with psoriasis, is quite severe and in the frozen stages
leads to disability. Conclusion
Patients diagnosed with psoriasis often turn to a dermatologist to correct their condition, not suspecting that, in addition to psoriasis, they may have one or more autoimmune diseases. Of course, in most cases, autoimmune conditions do not pose a mortal risk to human health, but still affect the quality of life. What should also be noted, some autoimmune diseases occur without severe symptoms, so a person can hardly suspect a problem and contact a specialized doctor for the necessary diagnosis and treatment.
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