Protection and recovery: slowing down mitochondrial cell apoptosis

Aging of the body in general and skin in particular – a complex process, one of the main factors of which is damage to mitochondria by reactive oxygen species.

The impact of these molecules leads to oxidative damage to cell components (lipids, proteins, nucleic acids, enzymes), a decrease in ATP production, and the accumulation of mitochondrial DNA mutations.

As a result, the cell cannot function normally and dies. This article estet-portal.com will focus on the main provisions of the theory of mitochondrial aging proposed by D. Harman in 1972, as well as ways to prevent premature skin aging.

Oxidative damage to mitochondria – one of the main factors of aging

All eukaryotic organisms are characterized by the presence of mitochondria – cellular organelles, the main function of which is – providing cells with the energy necessary for functioning (ATP molecules). The main processes occurring in mitochondria:

•    tricarboxylic acid cycle (Krebs);

•    oxidation of fatty acids;

•    carnitine cycle;

•    transport of electrons in respiratory chains;

•    oxidative phosphorylation.

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Mitochondria are also involved in apoptosis, intermediate metabolism, intracellular signaling, as well as in the metabolism of amino acids, lipids, cholesterol, steroids and nucleotides.

According to the mitochondrial theory of aging, dysfunction of mitochondria in various tissues due to a high level of mutation in the nuclear genes that control mtDNA synthesis, as well as the process of ATP production.

According to the mitochondrial theory of aging, the age-related decay of bioenergetics leads to an increase in the production and aggressiveness of ROS, a decrease in the efficiency of the mechanism of resistance to oxidative damage and cell repair.

During oxidative phosphorylation, some of the electrons form reactive oxygen species. Molecules of superoxide, hydrogen peroxide and hydroxyl radical lead to oxidative damage to various components of the cell, reduce the production of ATP, contribute to the accumulation of mtDNA mutations and a further increase in the amount of ROS. Such changes lead to dysfunction and cell apoptosis.

As you know, most age-related changes begin to develop long before old age. Therefore, the degree of effectiveness of measures aimed at preventing premature aging largely depends on the time of their implementation.

In other words, the sooner you start the process of preventing mitochondrial aging, the longer you can keep your skin young. To this end, the Italian company Dermophisiologique has developed a special line of preparations CHRONO AGE^® Cellular Repair System.

Chrono Age^® Cellular Repair System – line for the prevention of mitochondrial skin aging

CHRONO AGE^® Cellular Repair System guarantees the restoration of the skin's physiological balance, the resumption of natural functions, while protecting it from the effects of time, the sun and external factors. Chrono Age^® line products, thanks to high-tech liquid crystal formulations, allow the transport of active substances into the deep layers of the skin, which provides the absolutely necessary protection of cellular metabolism for the quality functioning of the skin and, therefore, to maintain its ideal appearance with points of view of anatomy and physiology.

Like all Dermophisiologique products introduced by by Medissa-K, the Chrono Age® does not contain mineral oils, parabens, synthetic dyes, allergenic fragrances; has a certified antioxidant effect.

CHRONO AGE Cellular repair system is the result of cutting-edge research using the latest bioavailable active ingredients specifically designed to stimulate cellular metabolic activity.

Active components of the Chtono Age line^®

ATiPenergy Patented Complex^® – a phytocomplex that restores and regulates the cell's energy metabolism. Consists of active ingredients of plant and marine origin. The synthesis of proteins increases: filaggrin, keratin, collagen and elastin.

Quercetin – bioflavonoid, has a powerful antioxidant effect, providing cleansing of the epidermis from free radicals that cause damage to cell membranes and aggravate skin aging.

Alpha Lipoic Acid – a compound from the class of vitamin-like substances with a pronounced antioxidant activity. It has protective properties and has a moderate anti-inflammatory effect, brightens the skin. prevents and even reverses the process of attaching glucose metabolites to collagen, as it improves the metabolism of glucose in the cell, preventing it from accumulating and damaging collagen in the skin.

CHRONOAGE^® Revitalizing Face Cream

Soft and multi-component cellular repair emulsion, maintains the biological age of skin cells, preserves their energy and vitality, contributing to the quality functioning of the skin. The product activates the key processes that regulate the functions of skin aging, optimize energy and metabolism, promote the protective function of the skin, which prevents and corrects all imperfections.

In the case of young and healthy skin, the product maintains and improves genetic and temporary aesthetic features, prevents the appearance of wrinkles, atony, spots, erythrosis, dryness and dehydration.

In chrono- and photo aging, the product improves the appearance of the skin, gives tone, firmness, elasticity and reduces wrinkles. The cream strengthens and protects delicate and sensitive skin, improves its barrier functions and counteracts exogenous and endogenous stress.

CHRONO AGE^® – cellular regenerator contains a set of natural active ingredients that have a certain regenerating effect on all skin components.

ACTIVE  INGREDIENTS: α-lipoic acid, quercetin, escin phytosomes, horse chestnut saponins, red grape polyphenols, chamomile, mallow and calendula extracts, phytic acid, papaya extract, ATiPenergy complex^®.

Selection of anti-age products according to aging morphotypes

Urban Base SPF 20 Protective Anti-Smog Cream Base

Toning Perfect Skin contains mineral and silicon-based skin feel technology.

All components of the technology are skin-like in composition, so the product instantly melts on contact with the skin and minimizes imperfections, wrinkles and enlarged pores.

The unique 4UV Defense Solar Filter System^® provides daily UV protection, combined with the innovative KEL-3 Complex™, which creates an effective barrier against air pollution (smog, dust, smoke).

With its light texture, the product is quickly absorbed and is an ideal make-up base. Ideal for those who play sports or those who spend a lot of time outdoors or in city traffic.

Result: skin is protected from the sun and external influences all day long and remains smooth and bright from morning to evening .

ACTIVE INGREDIENTS: KEL-3 Complex™, ceramides 1,3,6, phytic acid, red grape extract, witch hazel flower water.

Urban Base SPF 20 Protective Foundation Colored

Tonal Protective  new generation cream: protects the skin from pollution and UV rays and at the same time corrects skin tone, evens and smoothes the complexion with a natural effect against fatigue and shine. It has a LIGHT texture, can be applied alone or over a special face cream.

Compatible with regular makeup. Ideal for daily makeup. The MEDIUM shade adapts perfectly to the natural color of every skin type.

Urban Base Colored contains a system of certified sunscreens that provide daily protection  SPF 20 against UVA/UVB rays and signs of aging, and the exclusive KEL-3™ creates an effective barrier against external factors such as pollution and fine dust emissions.
CHRONO REPAIR MASK – anti-aging mask based on fucoidans (BIO-SKIN)

Contains the innovative Pollustop

®

complex that acts as a "shield" to protect the skin from smog, dust and other external influences.

^{Highly concentrated active natural fucoidan FucoreverseTM stimulates the synthesis of new collagen, while the Glialys 21 complex, composed of wheat proteins, creates a protective film on the skin, leaving it smooth, supple and hydrated all day long.}

ACTIVE INGREDIENTS: Pollustop

®

, Fucoreverse™ (algae extract), chicory extract,  Glialys 21 (hydrolyzed wheat proteins), gluconolactone, lactic acid, biosaccharides, caesalpia gum.

^{Chrono Age}®

Revitalizing Body Cream

^{Cream with a very soft texture and pleasant aroma. It activates the main processes that regulate the renewal and nutrition of cells, restores microcirculation and biological activity of the skin. Effectively helps prevent skin aging, restores energy and cellular metabolism, and strengthens the protective properties of the skin.}

This is a one-stop product from

Dermophisiologique

to treat all problems, in particular it gives tone and vitality to the skin, making it firmer, more elastic and velvety for long-lasting youth, and is an important prevention of stretch marks, cellulite, sagging skin of the abdomen, inner thighs and chest. Suitable for all skin types, men and women of all ages. ACTIVE INGREDIENTS: Pollustop®

, Fucoreverse®(hydrolysed algae extract), chicory root extract, Glialys 21(hydrolysed wheat proteins), gluconolactone, lactic acid, biosaccharides,  caesalpini prickly gum

^{CHRONO AGE}®

Professional Intense Repairing Serum

Acts on the key processes that regulate the functions of skin aging, thanks to active ingredients such as alpha lipoic acid, phytic acid and papaya.

Exclusive patented complex  ATiPenergy

®

optimizes energy and cellular metabolism, enhances the protective ability of the skin.

^{Aescin and red grape extract protect and improve microcirculation, prevent cellulite, atony, stretch marks and improve skin trophism.}

Penetration of active ingredients into the deep layers of the skin guarantees instant visible and long-lasting results. Suitable for all skin types, men and women of all ages.

ACTIVE COMPONENTS: complex  ATiPenergy

®

, Quercetin, Alpha Lipoic Acid, Phytic Acid & Papaya Extract, KEL-3 Complex™