Scientists at Japan's National Center for Global Health and Medicine have found that hair loss is one of the most common consequences following infection with COVID-19. Study author Shinichiro Morioka suggested that hair loss may have been caused by stress due to long-term treatment for COVID-19.
In this case, the first stage of therapy is the elimination of the main cause of hair loss. The second stage – active stimulation of cell proliferation and hair growth, for which Plinest Fast polynucleotides from the Italian company Mastelli are suitable.
Mastelli specializes in the development of preparations with a high concentration of polynucleotides for use in aesthetic medicine.
Daria Miguleva – dermatovenereologist, trichologist, cosmetologist, member of the Association of Trichologists of Ukraine, speaker at Totis.
- The importance of polynucleotides in the treatment of acute telogen hair loss
- Mechanism of action and possibilities of PDRN in trichology
- Plinest Fast (Mastelli) polynucleotides in the treatment of acute telogen hair loss
The importance of polynucleotides in the treatment of acute telogen hair loss
Dermal papilla – the main area of the hair follicle where fibroblasts are the dominant cells. Around the dermal papilla is a layer of undifferentiated cells that differentiate into keratinocytes and are involved in hair formation. There is a close relationship between the activity of fibroblasts, papillae and hair matrix cells. Fibroblast paracrine factors are involved in the formation of signals that lead to the formation and growth of new hair follicles. The functional deterioration of fibroblasts compromises the health and proper functioning of the scalp. Therefore, active stimulation of fibroblasts is crucial for the regeneration of follicles.
Basic Therapy Strategies:
- Reducing the effect of hormones on the hair follicle and/or eliminating the cause of stimulation of hair loss;
- Effective stimulating effect on cell proliferation and hair growth – this task is successfully polynucleotides solve.
Mechanism of action and possibilities of PDRN in trichology
Polynucleotides – unique discovery of modern science. This is a building material that restores the skin from the inside at the genetic level. "Bricks" polynucleotides recognize damaged DNA regions and replace them with healthy ones, stopping the process of chronic inflammation. The work of fibroblasts is activated, the production of collagen, elastin and hyaluronic acid increases.
Polynucleotides are an antioxidant that actively fights free radicals, being a "trap" for them.
Read also: Possibilities of using polynucleotides to stimulate growth eyebrows and eyelashes
Polynucleotides have anti-ischemic, anti-inflammatory and reparative effects. They increase local immunity, promote regeneration. Therefore, they have been successfully used for a long time in various fields of medicine, including aesthetic, specifically in trichology, allowing you to get excellent results.
PDRN – natural fractions of DNA, this is a mix of deoxyribonucleotides. They are obtained from the milk of salmon fish, by selective extraction using a technology developed by & nbsp; and patented by Mastelli specialists. It is this raw material that excludes the risk of transmission of prion infection (due to evolutionary remoteness), and specific, functionally significant, indicators of the DNA structure of salmon milt & nbsp; and DNA of human leukocytes are very close.
PDRNs are a substrate for the synthesis of their own DNA molecules (salvage pathway – recycling). PDRN preparations remove damaged areas of cells and contribute to their restoration. PDRN are extracted and purified at high temperatures. This procedure allows you to get more than 95% pure active substance with inactivated proteins and peptides. This guarantees the safety of the product and the absence of adverse immune reactions.
The source of raw materials is of great importance: salmon fish milt is most preferred for obtaining highly purified DNA without the risk of containing peptides and lipids that can remain in somatic cells.
Possibilities of polynucleotides in trichology:
- PDRN – a "prodrug" that supplies cells with sufficient amounts of deoxyribonucleotides and nitrogenous bases;
- Anti-inflammatory effect: relieves inflammation by inhibiting the pro-inflammatory factors TNF-.alpha. (tumor necrosis factor), IL-6, HMGB-1 (amphoterin) and stimulation of an increase in the level of anti-inflammatory cytokine (IL-10);
- Stimulation of angiogenesis (by acting on A2a receptors, the synthesis of VEGF, a vascular endothelial growth factor, is enhanced) & nbsp;
- Stimulation of skin regeneration (recovery of epidermal epithelization and restoration of the dermal matrix); & nbsp;
- Fibroblast stimulation – neocollagenesis;
- Activation of reparation – prevention of replacement of empty mouths of hair follicles with connective tissue, activation of reutilization of the skin's own nucleotides (salvage pathway).
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PDRN Action:
- Stimulate angiogenesis (growth of new blood vessels);
- Stimulate reparation processes (activate the reutilization process);
- Reduce the level of pro-inflammatory cytokines: TNF-.alpha. (tumor necrosis factor), IL-6, HMGB-1 (amphoterin);
- Increase the level of anti-inflammatory cytokine IL-10;
- Accelerate skin regeneration;
- They are free radical traps (protect against damage by metabolites, xenobiotics, temperature factors, etc.);
- Protect against UV radiation (block lipid peroxidation (LPO), have an antiradical and membrane stabilizing effect).
PDRN Security
Research has shown that:
Plinest Fast (Mastelli) polynucleotides in the treatment of acute telogen hair loss
During therapy with Plinest Fast polynucleotides from the Italian company Mastelli skin and hair follicles are updated at the DNA level, while they have a cumulative effect of action. According to its chemical and physical parameters, it is Plinest Fast that is excellent for injection into the skin of the scalp, taking into account all the features of the microcirculatory bed of this zone.
Plinest Fast (PDRN 15mg/2ml):
- Prevents hair loss;
- Stimulates hair growth and regeneration of the hair follicle;
- Promotes hair thickening.
Readings:
- Androgenetic alopecia;
- Shedding (diffuse telogen effluvium) and hair thinning;
- Postpartum hair loss;
- Thinning of the eyebrows after a long injury (plucking, tattooing);
- Before and after hair transplantation.
Plinest Fast – is a sterile liquid gel for intradermal administration of long-chain polynucleotides (highly purified PDRN from salmon milt).
Drug Benefits:
- Full biocompatibility with tissues and completely absorbable drug;
- No toxicity;
- Absolutely hypoallergenic;
- Fully controlled production chain;
- Made in Italy.
HPT-Polynucleotides™ - medicinal products of class III CE 0373, certified by the National Institute of Health.
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Mastelli polynucleotide certification indicates the safety and quality of products:
- GMP;
- ISO 9001;
- ISO 13485;
- RINA;
- CE 0373 (Instituto Superiore di Sanita);
- PR 129 18 – officially registered in Ukraine.
Plinest Fast – applications:
- Wash hair before treatment;
- Thorough disinfection of the treated area;
- Micropapular or classical technique – at a distance of 0.5 & ndash; 2 cm from each other;
- Injection depth – dermis;
- Field of therapy – scalp and eyebrows.
Application protocol:
PHASE 1: 1 treatment every 7-14 days during the month;
PHASE 2: 1 treatment every 2–3 weeks for 2–4 months.
Maintenance: 1 session every month or every 2 months.
Mastelli has 40 years of experience in the use of polydeoxyribonucleotides in the pharmaceutical industry. Polynucleotide Clinical Research Publications.
Clinical studies on the effects of Plinest Fast polynucleotides were conducted at the University of Pisa, Department of Dermatology, on 20 women with androgenetic alopecia.
Polynucleotide-HPT™ administered with 2 syringes containing 15 mg PN-HPT™ in micropapular technique.
Course of therapy: first month – 1 procedure per week for a month, the second, third and fourth month – 1 treatment every 2 weeks.
Plinest Fast results:
- Increased hair growth;
- Hair loss reduction;
- Reduction of androgenetic alopecia in 72% of patients;
- No side effects;
- High patient satisfaction.
PDRN Plinest Fast – preparation before hair transplantation. In this case, 6 procedures are performed before transplantation, or 3 before and 3 after hair transplantation. To enhance the effect, it is recommended to carry out a complex treatment of hair loss: intradermal therapy with polynucleotides Plinest Fast Mastelli + oral therapy with Plinest Care In (nucleotides, hyaluronic acid, vitamin E, vitamin C, coenzyme Q10, zinc, folic acid) .
Plinest Fast polynucleotides from the official distributor of TOTISPHARMA GROUP are safe and effective in the complex treatment of acute hair loss after COVID-19 by reducing hair loss, stimulating growth and improving hair quality.
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