Extended Youth Strategy: Possibilities of PDRN in Cosmetology

One of the trends in aesthetic medicine is that modern patients not only want to eliminate the signs of aging that have already formed, but also think quite early on how to prolong the youthfulness of the face and body as a whole. preventive medicine – ideology and methodology of personalized management of the state of health and body reserves, the main goal of which is – extension of a full healthy life of a person. In the aesthetic aspect, this means maintaining the functionality and appearance of facial and body tissues.

Plinest (Mastelli) polynucleotide revitalizing therapy with the use of polynucleotides (PDRN) from the official distributor of TOTISPHARMA GROUP LLC. 

• Main problems and tasks of revitalizing therapy 
• At what age is revitalization therapy indicated
• Mechanism of Action of Polynucleoid Drugs (PDRN)
• Benefits of Plinest polynucleotides for revitalization

The main problems and tasks of revitalizing therapy

Revitalizing therapy is aimed at restoring the functionality and condition of tissues characteristic of a young organism.

 

So, in addition to the skin, the face consists of a layer of subcutaneous fat, ligaments, muscles, deep fat, bone and cartilage tissues. Revitalizing therapy affects to a greater extent the connective tissue of the dermis, ligamentous apparatus, fascia, aponeurosis, muscles, bones and cartilage.

 

Revitalizing therapy – is: 

cell link;
•  
vascular link;
•  
stimulation of HA synthesis;
•  
stimulation of collagen synthesis;
•  
negative stimulation;
•  
target programs.
•  

To maintain normal function and a youthful appearance of facial tissues, it is important: 

the presence of a sufficient number of fibroblasts;
•  
activity of existing fibroblasts;
•  
Nutritional requirements that are supplied through the vasculature.
•  

Subscribe to our channel in

Telegram! 

Fibroblasts are responsible for the synthesis of the two main molecules of the extracellular matrix –

hyaluronic acid and collagen. Growth factors can stimulate the fibroblast to produce more HA or collagen, depending on the desired effect. 

It is important to understand that aging leads not only to loss of tissue volume, reduced synthesis of HA and collagen, but also to

accumulation of defective structures. Fibroblasts, which rapidly turn into fibrocytes, as well as damaged HA and collagen molecules, are difficult to naturally destroy. Catabolism, which increases with age, is primarily directed to new elements that function normally. 

Targeted programs include topical, lipolytic, vascular, depigmenting and decongestant therapies (depending on the indication).

 

Therefore, in order to ensure the normal functioning of the cells and the extracellular matrix, it is necessary to first get rid of the damaged structures. For this, chemical (peelings) and

physical (lasers, IPL, ultrasound) effects are used. 

At what age is revitalizing therapy indicated

 

Tissue aging processes start already after 20 years.

About this age: 

secretion of growth hormone, the maximum concentration of which is reached by the age of 10-16, is rapidly decreasing; growth hormone determines cell proliferation, protein synthesis and tissue volume;
•  
The amount of collagen, the main protein of youth, is almost halved and continues to decrease in the future.
•  

A unique procedure of biorevitalization with polynucleotides for rejuvenation of the neck and décolleté area 

Thus,

if you start actively working on maintaining the concentration of hyaluronic acid and collagen already at the age of 20, you can keep the tissues in excellent condition for the next 20-30 years. This is the essence of the philosophy extended youth. 

Mechanism of action of drugs with polynucleoids (PDRN)

 

For revitalizing purposes, hyaluronic acid molecules, peptides and polynucleotides are used. Considering that collagen is responsible for the elasticity and firmness of the skin, ligaments, muscles, bone and cartilage volume, our primary task is to maintain the quantity and quality of this protein. The most effective way to achieve this goal is to

use of Plinest (Mastelli) polynucleotides from the official distributor TOTISPHARMA GROUP LLC., since they, when combined with A2 receptors, stimulate the production of the body's own growth factors. This is the main advantage of PDRN in comparison with peptides, which give a quick but short-term effect.   

PDRNs long-term stimulate neocollagenesis by enhancing synthesis:

 

fibroblast growth factor;

 
• insulin-like growth factor, which acts as a somatotropic hormone;
 
• epidermal growth factor, which accelerates the recovery of the epidermis and has a slight stimulating effect on the synthesis of HA;
 
• endothelial growth factor, which determines the growth of the microvasculature necessary for tissue trophism.
 
Read also:

Lift up revitalization – modern technique of intensive therapy of connective tissue Besides, in the process of vital activity, cell DNA is constantly damaged by free radicals. A damaged cell loses its ability to divide, and the body is not always able to repair DNA. A sufficient amount of nucleotides helps to maintain the maximum working state of the cell, and therefore polynucleotides are also recommended to be taken orally. This allows you to prolong the result of PDRN injection. 

Studies demonstrate the effectiveness of PLINEST polynucleotides on ischemic flap: 

1) the volume of connective tissue increases by 2 times;

2) the epidermis recovers 3 times faster, and therefore it is recommended to combine PDRN with traumatic procedures – this provides a more pronounced effect and quick rehabilitation; 3) 3-fold increase in vascular growth. 

Polynucleotides stimulate fibroblasts well, and their effect is dose-dependent.

 

Course of procedures with Plinest polynucleotides for maximum effect:

 

in 20-30 years: revitalization with 1 syringe of Plinest polynucleotides is carried out at least 2 times a year, can also be combined with topical retinol if the skin is oily, with rashes or hyperpigmented;  at 30–40 years old: combined procedures will be more effective, calcium hydroxyapatite preparations,

peelings, retinol can be added to injections of Plinest polynucleotides for skin laxity.
•  
• Benefits of Plinest Polynucleotides for Revitalization  

Plinest – development of the Italian pharmaceutical company Mastelli, which conducts clinical studies of the effectiveness and safety of products in collaboration with leading medical universities.

   

skin revitalization;  connective tissue restructuring;

 

• neoangiogenesis; 
• suppression of inflammatory processes; 
• eliminate hyperpigmentation; 
• protection against UV and ionizing radiation. 
• Polynucleotide injections can be effectively combined with other rejuvenation methods, for example, in
• the LIFT UP® revitalizing protocol; therapy to get the maximum effect of connective tissue restructuring and cell regeneration. 

When choosing Plinest products, you can be sure of:  highest quality;

 

absolute security; 

no side effects;
•  
long term correction result;
•  
opportunities to preserve the youthfulness of facial and body tissues for a long time.
•  
• Preparations based on Plinest polynucleotides from the official distributor TOTISPHARMA GROUP LLC.
• – effective, safe and unique method of preserving the youth of facial and body tissues, which is suitable for all patients and ideally complements any correction plan. 

More interesting videos on our

YouTube-channel! 

Share: