What determines the course of atopic dermatitis

 

Over the past 15 years, allergies have taken a leading place in the list of the most common diseases. Atopic dermatitis (AD) is traditionally referred to as the most common and severe clinical course of allergic diseases. According to modern concepts, AD is an allergic skin disease that occurs in early childhood in individuals with a hereditary predisposition to atopic diseases.

Find out in the article on estet-portal.com what factors play a significant role in the manifestation and course of atopic dermatitis.

• study of the pathogenesis of atopic dermatitis at the present stage
• features of the course of atopic dermatitis in children
• Triggers of exacerbation of atopic dermatitis

The study of the pathogenesis of atopic dermatitis at the present stage

In the structure of dermatological morbidity, the share of this nosology is up to 20%, and in the structure of allergic diseases − 50 to 75%.

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In recent years, the incidence of allergic dermatoses in children of the first seven years of life has been growing especially dramatically. If in the 60s of the last century it was 0.1-0.5% in European countries, today it corresponds to an average level of 12%.

Skin functions, the violation of which causes the occurrence of dermatological pathologies

Beginning at an early age, AD quickly becomes chronic, causing suffering for a sick child, significantly impairs the quality of his life and is an economic, psychological and social burden for both the patient and his family members.

The development of AD at the present stage is considered as a consequence of complex interactions of genetic factors, the environment, infectious agents, defects in the barrier function of the skin and impaired immunological response.

This disease is characterized by polymorphism of clinical forms of skin lesions, staging of the course and the development of concomitant pathological changes in various organs and body systems.

Features of the course of atopic dermatitis in children

For children, certain features of the clinical course of AD are characteristic, which require an individual approach to the diagnosis and treatment of this disease, taking into account the form, stage, severity of skin lesions, the presence of respiratory symptoms of atopy, concomitant diseases, the patient's age, and the state of the immune system.

Only such an integrated approach will help maintain a relatively high quality of life in patients and improve the prognosis for AD.

 

 

Since atopic dermatitis is a chronic, relapsing disease,

the assessment of severity is carried out

not only on the basis of an assessment of the severity and prevalence of the pathological process on the skin, but also taking into account the history of the disease. A clinical study in 60 children with atopic dermatitis showed that the disease most often began at different ages, the duration of exacerbations averaged 1.5 months, and the frequency of exacerbations usually exceeded 4 times a year.

Atopic dermatitis: a studied disease with a mysterious history

 

 

It was established that in the group of children with severe atopic dermatitis, an earlier onset of the disease was observed, and the number and duration of exacerbations significantly exceeded the corresponding indicators for mild cases. At the same time, a good effect of therapy was observed only in the group with mild AD.

At the same time, in children with severe and moderate course, in most cases there was only a short-term effect of treatment

. In addition, in 16.8% of children in the third group, a torpid, treatment-resistant clinical

form of atopic dermatitis was observed. Atopic dermatitis exacerbation triggers

It should be noted that among the

factors that provoked an exacerbation of blood pressure, most often there were stressful situations, errors in the diet (consumption of citrus fruits, chocolate, spicy foods, fish, eggs), use of drugs (antibiotics, vitamins, salicylates ).

Seasonality of exacerbations was also noted: most often (63.3%) exacerbations occurred in the autumn-winter period, in 14.9% of the examined patients relapses occurred in the spring-summer period, in 31.7% of children, exacerbations of the disease did not were associated with the season.

Emollients and food allergies: what's the connection?

This pattern can be explained by a fairly wide range of causally significant allergens

(pollen, household, mite, food, epidermal, etc.), as well as the predominance of their influence at one time or another of the year. It has been established that the course of atopic dermatitis is characterized by polymorphism of clinical forms of skin lesions, a certain staging of the course and the presence of typical complications. Therefore, the diagnosis of this disease was largely based on a typical clinical picture.

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