The role of antioxidants in the metabolic processes of the skin

The health and beauty of the skin is an essential part of a person's overall well-being. Among the various active substances, antioxidants are included in anti-aging cosmetics due to their beneficial effect, as well as preventing and minimizing the signs of skin aging.

This statement holds true for the cosmetics industry as well, providing a better understanding of the science-based formula of modern cosmetics and supporting the need for innovative antioxidants as a staple in skincare.

Learn in the article on estet-portal.com about the physiological mechanisms of the influence of antioxidantin on skin aging processes and the possibility of their application in the field of aesthetic medicine.

The role of antioxidants in the metabolic processes of the skin

Oxidative stress is defined as an imbalance between the formation of oxidative free radicals and the antioxidant defense capacity of body cells.

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Oxidative stress has been identified as a leading link in many dermatological diseases, including vitiligo, atopic dermatitis, alopecia areata, photoaging, and carcinogenesis. Most free radicals in the body exist in the form of reactive oxygen species (ROS).

Excess free radicals damage not only cell DNA, but also cell proteins and lipids.

In living cells, ROS are continuously generated as a metabolic byproduct of glucose oxidation in mitochondria. This reaction occurs in absolutely all cells of our body. In addition, environmental stimuli such as ionizing and ultraviolet (UV) radiation, environmental pollutants, contact allergens, and drugs are powerful inducers of ROS production. Inflammatory cytokines are also responsible for ROS generation.

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Because the skin is the outermost organ of the body and is constantly in contact with these triggers, these oxidative stimulants negatively affect proper cell differentiation and barrier function of the skin. Therefore, it is so important to provide skin cells with the necessary amount of antioxidants.

Antioxidants in the neutralization of free forms of oxygen

Excessive ROS production must be neutralized or minimized by antioxidants to maintain skin homeostasis. Antioxidant molecules, including glutathione, vitamin E, and vitamin C, work together with enzymatic antioxidants such as NAD (P) H, heme oxygenase-1 (HO-1) and glutathione-S-transferase.

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The induction of these enzymes is supported by nuclear regulatory factor-2 (NRF2), which is the main "switch" for signaling antioxidants in the free radical neutralization circuit, which cause damage to skin membranes and are the basis of photoaging and age-related changes in the skin.

Various phytochemicals and plant extracts exert their antioxidant properties by activating the NRF2 system in epidermal keratinocytes. Some antioxidant substances also increase the expression of filaggrin (FLG), which plays a key role in maintaining epidermal barrier function.

Antioxidants act on reactive oxygen species, thus slowing down the aging process of the skin.

Ascorbic acid, tocopherol and their derivatives have consistently been the most commonly used antioxidants in cosmetic formulations over the past 8 years, followed by niacinamide and retinyl palmitate. Seven ascorbic acid derivatives are currently used in anti-aging skin care formulations.

Antioxidants in cosmeceuticals

Following major discoveries in the field of dermatology and cosmetology Hyalual has developed a line of highly effective innovative products for visible daily results. ANTIOXIDANT MULTIVITAMIN SERUM multivitamin serum with powerful antioxidant protection has become a staple in complex skin care.

Hyalual's Lightweight Serum is high in natural actives and contains antioxidants to help visibly transform skin, maintain skin's protective properties and promote a more even skin tone. A blend of amino acids protects the skin from free radicals and environmental damage.

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Peptide-based cosmeceuticals help natural collagen and elastin work in the fight against wrinkles, and improve turgor. Hyaluronic acid moisturizes the skin and makes it more elastic. Antioxidant-rich multivitamin complex helps keep skin smooth, hydrated and radiant for a healthier, fresher complexion.

Whey Antioxidant Differences

Unlike other products on the market of aesthetic medicine, in the composition of the multivitamin serum, the company Hyalual included not individual derivatives of plant components, but the LPD´s MULTIVITAMIN Complex. This complex contains vitamins A, C, E, F, which accelerate cell renewal processes, stimulate collagen synthesis and reduce wrinkles, provide an antioxidant effect.

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The tripeptide in the composition of cosmeceuticals contains free amino acids, which are "building"; material for the skin and stimulate collagen synthesis, improving skin texture and reducing the appearance of wrinkles, while the innovative NIO-SENSIL − a balanced hydration system, necessary for cell growth and development, has strong anti-inflammatory and antioxidant properties.

Our skin is inevitably exposed to UV rays and environmental triggers. To a greater or lesser extent, these external stimuli cause oxidative stress and accelerate the aging process. Therefore, carefully treat your daily care to allow the skin to remain healthy, smooth and radiant for as long as possible!

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