Therapy of hyperpigmentation without harm to health: 5 effective steps to normalize melanogenesis with ME Line

The appearance of age spots on the skin, associated with the peculiarities of the hormonal background or regular exposure to ultraviolet radiation, can cause psychological discomfort for the patient.

Therapy of hyperpigmentation using products based on components that inhibit the enzyme tyrosinase helps to reduce the severity of the pigmented area, but cannot prevent the recurrence of hyperpigmentation and guarantee the patient relief from this problem.

The use of products based on hydroquinone and trethionine (retinoic acid), despite their effectiveness, is associated with risks to patient health and delayed complications.

Normalize the process of melanogenesis from the first stage and eliminate age spots became possible with the help of innovative safe components that are part of preparations ME Line from the Spanish brand Innoaesthetics.

How to do this, in the article estet-portal.com tells the general practitioner, brand -manager of the company TOTISPHARMA GROUP LTD. – Baranova Evgenia Davidovna.

• How to prevent melanin biosynthesis from starting
• The safest ingredients for hyperpigmentation therapy
• Mechanism of action of ME Line preparations: total control of melanogenesis
• Proven effectiveness of ME Line products: research results

                    

Evgenia Davidovna Baranova – General Practitioner, Brand Manager TOTISPHARMA GROUP LTD .

How to prevent melanin biosynthesis from starting

Effective therapy of hyperpigmentation is possible only due to influence on each of the stages of the melanin biosynthesis process.

Melanin biosynthesis (melanogenesis) – it is a complex biochemical process in which the copper-containing enzyme tyrosinase and alpha mela-stimulating hormone (alpha-MSH) play a major role.

Let's look at the key steps of this process:

1. The keratinocyte is exposed to increased ultraviolet, which can lead to DNA damage;
2. Damaged DNA stimulates the expression of POMC (pro-opiomelanocortin) - a precursor protein of alpha-MSH (alpha-melanostimulating hormone);
3. Alpha-MSH binds to a receptor on the melanocyte, transmitting a signal of cell damage by ultraviolet light, and initiates starting the process of melanogenesis;
4. In melanocyte under the action of the enzyme tyrosinase, melanin is synthesized from the amino acid tyrosine;
5. Melanocyte, united by its processes with more than 30 keratinocytes, transmits through them melanosomes containing melanin;
6. Inside keratinocytes, melanosomes release melanin, which protects the cell nucleus from further damage by ultraviolet light.

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Preparations ME Line provide a completely new, revolutionary way of influencing the process of melanogenesis, including the innovative component – Melanostatin-5.

Melanostatin-5 binds to alpha-MSH receptors on melanocytes, competitively inhibiting the action of the hormone, and prevents melanin biosynthesis from the first stage!

Melanostatin-5 is included in ME Line products for professional home post-peel care:

• ME Line 02 Caucasian Skin Night;
• ME Line 02 Spots;
• ME Line 02 Intimate. 

The safest ingredients for hyperpigmentation therapy

Today, the manufacture, import, export and sale of any cosmetic products containing hydroquinone in concentrations greater than 5% are prohibited by the FDA due to high risks of delayed complications in patients.

However, many drugs still include this component in their compositions, reducing the concentration to 2-4%. However, the duration of use of such preparations is strictly limited to a period not exceeding 2 months.

For the innovative preparations ME Line aimed at the professional therapy of hyperpigmentation, arbutin – a safe analogue of hydroquinone derived from bearberry leaves that does not have cytotoxic and carcinogenic risks.

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Also, retinal – a derivative of vitamin A, which is converted much faster than other retinoids into the active form (retinoic acid), but does not cause active peeling, does not aggravate skin sensitivity and does not require precautions in use in the form of compliance with "retinoic" x steps». Follow us on

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! Mechanism of action of ME Line products: complete control of melanogenesis Thanks to innovative formulas, ME L

ine

preparations act directly on the source of the problem, normalizing the disturbed melanogenesis process at each stage:

competitively inhibit receptors for alpha-melanostimulating hormone (Melanostatin-5);

block the tyrosinase enzyme, preventing melanin biosynthesis (
• Kojic, Phytic and Azelaic acids
, as well as
• Arbutin, Resorcinol and Tranexamic acid ); hinder the transfer of mature melanosomes from melanocytes to keratinocytes ( Niacinamide, Retinal, Glutathione);
contribute to the destruction (lightening) of existing melanin inside keratinocytes (
• Ascorbic, Thioctic and Lactobionic acids
);
• provide easy removal (exfoliation) of pigmented keratinocytes (Lactic, Salicylic and Mandelic acids).
• ME Line – these are 5 effective steps to skin without hyperpigmentation! Each
ME Line

product has a numerical code on the packaging indicating the sequence of its use, as reflected in

clear therapy protocols

:

00 – skin preparation for peeling;

• 01 – professional peels and mesotherapy;
• 02 – professional home post-peel care;
• 03 – daily skin hydration and restoration;
• 04 – protective BB cream with SPF 30 and tinting effect;
• 05 – mask to consolidate the results of therapy.

Complex Systems ME

Line directed to therapy: melasma (chloasma) – ME Line Caucasian Skin;

solar lentigo –
• ME Line Spots;
• pigmentation of intimate areas – ME Line Intimate;
• pigmentation of the area around the eyes – ME
• Line Dark Circles. Each peel from line 01 must be supplemented with home care preparations from
lines

02 and 05, which reinforce and fix therapeutic peeling results. The use of preparations from the lines 03

and

04 provides hydration, restoration and additional protection for skin prone to hyperpigmentation. It is important to remember that the component that prevents the recurrence of pigmentation (Melanostatin-5

) is part of the preparations from the line

ME Line 02. It is these drugs that provide guaranteed and long-lasting results of therapy with the help of complexx systems

ME Line.

Melasma Area and Severity Index (Melasma Area and Severity Index)

in

98 patients with melasma

who underwent hyperpigmentation therapy with the

complex system

ME Line Caucasian Skin. The achieved results demonstrate disappearance of mild melasma in 30.5% of patients treated with ME Line

for 4 weeks and in recommended three-month course of therapy

. After 12 weeks of ME Line treatment, all cases of severe hyperpigmentation (13.7% at baseline) were resolved.

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Benefits of complex systems for the treatment of hyperpigmentation ME

Line

:

high efficacy and safety of drugs, confirmed by clinical studies;

Spanish specialized Innoaesthetics laboratory, advanced equipment, innovative developments; Professional formulations

with powerful targeted action on hyperpigmentation therapy;

• Synergistic effect of products within each therapeutic line;
• clear protocols for the use of ME Line preparations, including preparations for professional use and for home post-peel care;
• appreciable result already after 2 procedures, complete removal of age spots after 3 months of the recommended course of therapy.
• Brand
Innoaesthetics
• and complex systems for the treatment of hyperpigmentation
ME

GROUP

LTD. More detailed information and official protocols of complex ME Line systems can be obtained from the managers of TOTISPHARMA GROUP

LTD. or by phone: +38 094 855 15 15.